Anti-Fertility Activity of Pterocarpus Santalinus Heart Wood Extracts in Female Rats

Author(s)

Azamthulla, M., Balasubramanian, R., Kavimani, S.

Author's Affiliation

Abstract

The present study was undertaken to evaluate the anti-fertility activity of Pterocarpus santalinus heart wood using different experimental models such as Anti-implantation activity, Estrous cycle study, and estrogenic /Anti-estrogenic activity. Toxic symptoms and mortality was studied for both ethanol and chloroform extract of Pterocarpus santalinus heart wood and both the extracts were found to be well tolerated up to 2g/kg. Hence 1/4^th (500mg/kg) and 1/10^th (200mg/kg) of the dose of this were selected for the study. Ethynyl estradiol 0.1mg/rat, i.m. (EED) was used as standard drug. The ethanol extract of Pterocarpus santalinus heart wood in both doses (500mg/kg and 200mg/kg) possesses anti-implantation activity by significantly reduced the number of implantation sites. Administration of ethanol extract to immature rats at doses 500 and 200mg/kg showed increase in the ovary weight and also resulted in increase in the levels of alkaline phosphatase and glucose levels but also showed a significant increase in the cholesterol level and hence proved to be an anti-fertility agent. The chloroform extract of Pterocarpus santalinus heart wood in both doses (500mg/kg and 200mg/kg) also possesses anti-implantation activity by slightly reduced the number of implantation sites. In immature rats the chloroform extract results in increase in the ovary weight and slightly increase in alkaline phosphatase, cholesterol and glucose levels and showed anti-fertility activity. Hence, it is concluded that the ethanol extract of Pterocarpus santalinus heart wood in both doses (500mg/kg and 200mg/kg) showed more anti-fertility activity then chloroform extract of Pterocarpus santalinus heart wood.

Keywords

Pterocarpus Santalinus Heartwood, Anti-Implantation Activity, Estrous Cycle

Cite This Article

Azamthulla, M., Balasubramanian, R., & Kavimani, S. (2014). Anti-Fertility Activity of Pterocarpus Santalinus Heart Wood Extracts in Female Rats. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 355-374.