Antidiabetic Activity of Methanolic Extract of Polygonum glabrum Wild Leaves in Diabetic Rats

Author(s)

Faheemuddin, M.D., Ahmed, A., Kumar, S., Shirisha.

Author's Affiliation

Abstract

To evaluate the anti-diabetic activity of the Plant leaves of Polygonum glabrum in alloxan induced diabetic rats. Method: Diabetes was induced in Wistar rats using freshly prepared solution of Alloxan monohydrate (100 mg/kg b. wt.) by Intraperitoneal route of drug administration. Methanolic extract of Polygonum glabrum (200, 400 mg/kg bwt/p.o) was prepared freshly, administered to alloxan induced diabetic rats for 28 days. The standard drug glibenclamide (10 mg/kg of b. wt) orally. Blood glucose levels was estimated on 0, 7^th, 14^th, 21^st and 28^th days, serum glucose level, lipid profile, and histopathological changes in pancreas were examined after 28 days. OGTT was performed by administration of 200 and 400 mg/kg b.w/p.o of methanolic extract of Polygonum glabrum and 10 mg/kg b.w /p.o of Glibenclamide to different groups respectively in normal rats. Results: significant(p<0.001) results were observed in the estimated parameters like reduction in blood glucose , Improved in regeneration of beta cells of langerhans of pancreas in rats by histopathological studies. Conclusion: The results were suggested that the whole plant extract of Polygonum glabrum having potent antidiabetic activity on alloxan induced diabetic rats.

Keywords

Anti-diabetic, Polygonum glabrum, alloxan induced diabetic rats, OGTT, Glibenclamide

Cite This Article

Faheemuddin, M.D., Ahmed, A., Kumar, S., & Shirisha. (2016). Antidiabetic Activity of Methanolic Extract of Polygonum glabrum Wild Leaves in Diabetic Rats, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(1), 172-179.