Antihyperglycemic Activity of Mentha piperita Ethanol Leaves Extract on Streptozotocin Induced Diabetic Rats

Author(s)

Chandirasegaran, G., Elanchezhiyan, C., Suhasini, S., Babby, A.

Author's Affiliation

Abstract

Mentha piperita (Pepper mint) has been used medicinally for thousands of years. In the present study the antihyperglycemic effect of Mentha piperita was investigated experimentally. The diabetes was induced by intra peritoneal injection single dose of Streptozotocin (STZ) (50mg/kg b.w). After three days (72hr) of induction of diabetes, the diabetes animals were treated with ethanolic extract of Mentha piperita (300mg/kg b.w). The Mentha piperita treated diabetic rats significantly decreased the level of blood glucose and creatinine as well as increased level of insulin, glycogen, body weight. These finding demonstrated that Mentha piperita possess antihyperglycemic activity against STZ induced diabetic rats. The antidiabetic effects of Mentha piperita was compared with standard reference drug glibenclamide.

Keywords

Mentha piperita, Antihyperglycemic, Streptozotocin, Glibenclamide

Cite This Article

Chandirasegaran, G., Elanchezhiyan, C., Suhasini, S., & Babby, A. (2014). Antihyperglycemic Activity of Mentha piperita Ethanol Leaves Extract on Streptozotocin Induced Diabetic Rats. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(3), 113-117.