Antihyperglycemic and Antihyperlipidemic Effect of Aqueous Fruit Extract of Momordica charantia against Alloxan Induced Diabetic Rats

Author(s)

Rajalakshmi, A., Senthilkumar, B., Devi, K.

Author's Affiliation

Abstract

Momordica Charantia is used extensively in the indigenous system of medicine as an anti-diabetic agent. The current investigation focuses on the serum insulin augmentation, anti-hyperglycemic and anti-hyperlipidemic property of aqueous fruit extract of Momordica Charantia on alloxan induced diabetes in male albino rats. The diabetes induced animals were fed with the fruit extract at 250mg/kg body wt and 350mg/kg body wt. The aqueous fruit extract administrated animals revealed a significant (P<0.001) increment of serum insulin levels, higher reduction in hyperglycemia and hyperlipidemia when compared to the diabetic control rats (P<0.001). The histological studies of the endocrine region of pancreas of diabetic animals revealed shrinkage of ß-cells of islets of langerhans. The aqueous fruit extract treated animals revealed restoration of ß-cells.

Keywords

Momordica Charantia, Alloxan, Hyperglycemia, Hyperlipidemia

Cite This Article

Rajalakshmi, A., Senthilkumar, B., & Devi, K. (2013). Antihyperglycemic and Antihyperlipidemic Effect of Aqueous Fruit Extract of Momordica charantia against Alloxan Induced Diabetic Rats. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(4), 54-60.