Antihyperlipidemic and Biochemical Effect of Callus and Leaf Extracts of Pergularia Daemia (Forssk.) Chiov. on Blood Serum of Streptozotocin-Attenuates White Albino Rats

Author(s)

Kumar, V. P., Ramesh, N.

Author's Affiliation

Abstract

The aim of the present study was to evaluate the antihyperlipidemic potential and biochemical parameters of various leaf extract of P. daemia.  Extract was administered orally at a dose of 100, 200 and 300 mg/kg b.w in streptozotocin induced diabetic rats for 21 days. To assess the antihyperlipidemic activities and biochemical effects of this extract, we have also measured the serum levels of total cholesterol, triglycerides, phospholipids, Serum protein, albumin and haemglobin. The various leaf extract of P. daemia also resulted a significant recovery in above mentioned biomarkers of lipid profile and biochemical parameters when treated to STZ-induced diabetic rat. Resettlement of all these parameters after the treatment of ethanol, chloroform, aqueous extract of leaf of P. daemia is promising which has been reflected here from the comparison with the antidiabetic drug i.e. glibenclamide. The result of this experiment demonstrated that the leaf extracts of P. daemia possess a promising antidiabetic efficacy.

Keywords

Antidiabetic, Pergularia daemia, Leaf, Streptozotocin, Anti-hyperlipidemic, Biochemical Parameters

Cite This Article

Kumar, V. P., & Ramesh, N. (2014). Antihyperlipidemic and Biochemical Effect of Callus and Leaf Extracts of Pergularia Daemia (Forssk.) Chiov. on Blood Serum of Streptozotocin-Attenuates White Albino Rats. International Journal for Pharmaceutical Research Scholars, 3(1), 492-500.