Antimicrobial Peptides: A Review on its Types, Mechanism of Action, Synthesis and Therapeutic Applications

Author(s)

Mondal, N.R., Jagdale, D.M.

Author's Affiliation

Abstract

Over last two decade, conventional antimicrobial drugs are losing their effectiveness due to drug resistance which may lead to serious problems. As a result there is a need for continuous research on other treatment approaches, one of which is antimicrobial peptides. Antimicrobial peptides (AMPs) are small (6 to 100 amino acid) amphipathic molecules with wide range activity against bacteria, protozoa, yeast, fungi, viruses and tumor cells. A large numbers of antimicrobial peptides are under the pre-clinical and clinical trials for treatment of lethal infections. In this review, we have discussed the different types of AMPs, its mechanism of action, synthesis and therapeutic applications.

Keywords

Antimicrobial Peptides, α-Helical, Antibiotic Resistance

Cite This Article

Mondal, N.R., Jagdale, D.M. (2016). Antimicrobial Peptides: A Review on its Types, Mechanism of Action, Synthesis and Therapeutic Applications, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(2), 72-81.