Approaches to Pulsatile Drug Delivery System

Author(s)

Farswan, R., Tangri, P., Lakshmayya

Author's Affiliation

Abstract

Pulsatile drug delivery system (PDDS) is a popular drug delivery system, intended to deliver a rapid, transient and able to provide the release of  two subsequent drugs which quantify the medication release after a predetermined off-release period (lag time). PDDS has number of advantages over the other oral doses form, it avoids the degradation of drugs in the stomach & its first-pass metabolism, capability to simultaneous administration of two different drugs, allows their release at different sites within the GIT and provides a release burst of drug at one or more predetermined time intervals as per patient requirements. The PDDS having a unique mechanism of drug delivery, in which the drug release rapidly after the lag time, there are numbers of PDDSs formulations available in the markets which replaced the modified-release dosage forms.

Keywords

Pulsatile, Chronotherapeutic, Drug delivery system, Lag time

Cite This Article

Farswan, R., Tangri, P., Lakshmayya. (2015). Approaches to Pulsatile Drug Delivery System, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(2), 80-95.