Assessment of Risk Factors for Ischemic Kidney Disease in Patients with Impaired Renal Function

Author(s)

Yasmeen, G., Dawani, M. L., Mahboob, T.

Author's Affiliation

Abstract

The present study was planned primarily to investigate the risk factors associated with renal ischemia in chronic kidney disease and secondarily to measure the incidence of disease. Observational study conducted in collaboration with a tertiary care hospital. All patients visiting nephrology unit meeting basic criteria of having at least 5 year diabetes mellitus, 10 year hypertension, dyslipidemia, age >55 year were recruited for kidney ischemia through Doppler scan. Written consent was obtained on a questionnaire inquiring about personal family medical history. Mean age was 48.2 ± 11 year. Male gender was significant factor (p<0.001) comprising 73.8%. The most prevailed risk factors were diabetes mellitus (61.2%), hypertension (43.7%), smoking (34.8%), raised cholesterol (52%), low HDL-C (35.4%) and increased triglycerides (61.4%) who contributed significantly in developing ischemic changes with (p<0.01, 0.0001, 0.0005, 0.0005, 0.05, 0.05) respectively. The calculated odd ratios at 95% confidence interval, for age>46 year (OR 0.5902, p<0.01), diabetes mellitus (OR 0.6677, p<0.05), hypertension (OR 4.1339, p<0.0001), male gender (OR 0.5320, p<0.001), smoking (OR 0.4862, p<0.0005), hypercholesterolemia (OR 2.1004, p< 0.0005), low HDL-C (OR 1.4567, p<0.05), obesity (OR 1.6345, p<0.05). While IHD, oral tobacco consumption, use of alcohol remained non-significant. It was observed that IKD positive had relatives with diabetes, hypertension, stroke, obesity and renal disease, significant as individual risk factor. Renal ischemia incidence was 11.5% among CKD. More large scale multi-centre studies are required to get the true prevalence and actual picture of disease.

Keywords

Ischemic Kidney Disease, Diabetes Mellitus, Hypertension, HDL-C, LDL-C

Cite This Article

Yasmeen, G., Dawani, M. L., & Mahboob, T. (2014). Assessment of Risk Factors for Ischemic Kidney Disease in Patients with Impaired Renal Function. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(1), 839-846.