Comparative Evaluation of Analgesic Activities of Aniseed Essential and Fixed Oils

Author(s)

Jamshidzadeh, A., Hamedi, A., Altalqi, A., Najibi, A.

Author's Affiliation

Abstract

Different dosage forms of Aniseed oil have been used in Persian traditional medicine for their pain killer and analgesic properties but their effects have not been compared scientifically. Aniseed essential oil was extracted using hydro-steam distillation method. Fixed oil was extracted with petroleum ether and oils composition was analyzed by GC-MS. Phenolic content of fixed oil was determines spectrophotometrically.  Different concentrations of essential and fixed oil were injected i.p. to the rats and animals were evaluated for analgesic effect at three times (30, 60 and 120 min) after injection by tail-flick and formalin tests. Major constituents of essential and fixed oil were anethole (87.58%) and 9-octadecenoic acid (74.55%). All doses of fixed and essential oil after 60 min had the highest significant analgesic effect compared to the control group (P < 0.01). The analgesic effect of the essential oil (500 mg/kg) was higher than paracetamol (100 mg/kg) in chronic phase of pain in formalin test (P < 0.05). Also, in both tests analgesic effects of essential oil was higher than fixed oil in all doses but it was significant just at 500 mg/kg (P < 0.05). Analgesic effects of essential and fixed oils of P. anisum are comparable with paracetamol but essential oil in higher doses was significantly more effective than fixed oil.

Keywords

Aniseed, Analgesia, Essential oil, Fixed oil, Pain, Pimpinella anisum, Rat

Cite This Article

Jamshidzadeh, A., Hamedi, A., Altalqi, A., & Najibi, A. (2014). Comparative Evaluation of Analgesic Activities of Aniseed Essential and Fixed Oils. International Journal for Pharmaceutical Research Scholars, 3(1), 227-235.