Comparative Hypoglycaemic Study of Methanolic Extract of Psidium guajava (Guava), Tamarindus indica (Tamarind) & Azadirachta indica (Neem) in Alloxan-induced Diabetic Rat with Reference to the Standard Drug Metformin

Author(s)

Bhattacharjee, M., Roy, L.

Author's Affiliation

Abstract

Our aim of the study was to compare the anti-diabetic activity of already established methanolic leaf extract of Psidium guavaja, Tamarindus indica and Azadirachta indica over Alloxan-induced diabetic rat by using Metformin as a standard drug. Extract was prepared by proper drying, sieving followed by soxhelation and evaporation of the excess solvent by rotary vacuum evaporator. 2% solution of Alloxan was used for induction of diabetes to the animals both in long term (1, 7, 14, 21 and 28^th day study) and short term study (1, 2, 3, 4 and 6 hours). In long term study, more significant decrease of blood sugar level had been observed in case of Azadirachta indica (86.7±0.62 mg/dL - High dose value on 28^th day) than Tamarindus indica (98.3±0.86 mg/dL - High dose value on 28^th day) and Psidium guajava (106±0.73 mg/dL - High dose value on 28^th day) – where value for standard drug was reported as 73.9±0.2 mg/dL. In OGTT study also, more significant lowering of Blood glucose level had been observed in Azadirachta indica (81.9±0.79 mg/dL in 4 hrs high dose) in respect to Tamarindus indica (90.3±0.87 mg/dL in 4hrs high dose) and Psidium guajava (96.5±0.73 mg/dL in 4hrs high dose) – where Metformin shows value of 79.1±0.4 mg/dL (4 hrs). So, it can be concluded from the study that methanolic extract of Azadirachta indica shows better antidiabetic potential in comparison to methanolic extract of Tamarindus indica and Psidium guajava on Alloxan induced diabetic rat model in respect to standard drug Metformin.

Keywords

Diabetes Mellitus, Psidium guavaja, Tamarindus indica, Azadirachta indica, Alloxan, OGTT, Comparative study

Cite This Article

Bhattacharjee, M., Roy, L. (2017). Comparative Hypoglycaemic Study of Methanolic Extract of Psidium guajava (Guava), Tamarindus indica (Tamarind) & Azadirachta indica (Neem) in Alloxan-induced Diabetic Rat with Reference to the Standard Drug Metformin, International Journal for Pharmaceutical Research Scholars (IJPRS), 6(4), 3-11.