Comparitive Antitubercular Activity of Sulfadrug Substituted 1, 4-Thiazines and 1, 3- Thiazines

Author(s)

Sindhu, T. J., Chandran, M., Paul, D., Bhat, A.R., K. Krishnakumar.

Author's Affiliation

Abstract

Tuberculosis has an on-going impact on global public health in the 21^st century. Although many active antitubercular agents have since been developed, a disturbing co-occurrence with the use of present drugs as single agent has developed drug resistance. This has made use to investigate for new thiazine derivatives for finding more effective antitubercular agents. The present study was designed to synthesise some novel sulpha drug substituted 1, 4- thiazines by using O-amino thiophenol, maleic anhydride, ethanol and formaldehyde and also 1, 3-thiazine was prepared from chalcones obtained by Claisen Schimidt condensation reaction.  Then the synthesised compounds were screened for their antimycobacterial activity by using Micro plate Alamar Blue Assay (MABA). The results indicate 1, 4-thiazine derivatives and 1, 3- thiazine derivative have considerable antimycobacterial activity. Out of the 5 derivatives, E4 (Sulfamethoxazole substituted 1, 4- thiazine) is most effective and showing activity at 25μg/ml. The study suggests that 1, 4-Thiazine derivatives shows potent antimycobacterial activity than 1, 3-thiazine derivative.

Keywords

Tuberculosis, 1, 4-Thiazines, 1, 3-Thiazine, MABA method

Cite This Article

Sindhu, T. J., Chandran, M., Paul, D., Bhat, A.R., & K. Krishnakumar. (2014). Comparitive Antitubercular Activity of Sulfadrug Substituted 1, 4-Thiazines and 1, 3- Thiazines. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(1), 24-30.