Design and In Vitro Evaluation of Sustained Release Matrix Tablets of Repaglinide

Author(s)

Arakeri, V., Kumar, A. P., Kulkarni, S. V.

Author's Affiliation

Abstract

The objective of the present work is to design sustained release matrix tablets of Repaglinide using Prosophis juliflora gum and HPMC K-100, Ethyl cellulose. Tablets were prepared by wet granulation method. Repaglinide is one of emerging short acting drug. Granules were prepared and evaluated for loose bulk density, tapped bulk density, compressibility index and angle of repose. The developed tablets were subjected to various tests for physical parameters such as thickness, hardness, friability, drug content and in vitro release studies. Release kinetics was evaluated by using United States Pharmacopeia USP type II dissolution apparatus. The in vitro dissolution study was carried out for 12 hrs. For first 2hrs in 0.1 N hydrochloric acid (pH 1.2) followed by using phosphate buffer pH 7.4 for the remaining 10 hrs. The results of dissolution studies indicated that formulations containing natural gum Prosophis juliflora gum showed better dissolution than synthetic gums (HPMC K-100, Ethyl cellulose). The dissolution study proved enhanced sustained release when dried Prosophis juliflora gum was used as a matrix forming material.

Keywords

Sustained Release Matrix Tablet, Repaglinide, Prosophis Juliflora Gum, HPMC K-100, Ethyl Cellulose

Cite This Article

Arakeri, V., Kumar, A. P., & Kulkarni, S. V. (2014). Design and In Vitro Evaluation of Sustained Release Matrix Tablets of Repaglinide. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(4), 142-152.