Design, Synthesis and Anti-Inflammatory Activity of Certain Fused Novel Thienopyrimidines Derivatives

Author(s)

Ahmed, O., Rahman, M. H. U., Najeeb, A., Noorullah, S. M., Basha, S. A. A.

Author's Affiliation

Abstract

The capital aim is to admix and characterize atypical thienopyrimidine derivatives and covering them for anti-inflammatory activity. An alternation of 4 substituted cyclopenta [4, 5] thieno [2, 3-d] pyrimidine (5a-5e) were synthesized from cyclopentanone. The actinic compounds, characterized on the abject of satisfactory analytic and ashen (¹H-NMR, Mass and elemental data). Studies were agitated out for the actinic compounds which were as able evaluated for anti-inflammatory activity in albino rats by appliance of a carrageenan induced paw edema method. The actinic compounds showed adequate arise that two of the compounds 5a (Ar = 4-chloro cinnamoyl) and 5e (Ar = benzyl hydrazide) showed 50% anti-inflammatory activity as compared to accustomed biologic indomethacin afterwards 2hr. All the compounds showed negligible activity afterwards 4 hr. We abode the accustomed admixture of atypical thienopyrimidine, as able as their spectral characterization, and anti-inflammatory activity which, for some, is aloft to currently acclimated as anti-inflammatory agents.

Keywords

Anti-inflammatory, Cyclopentanone, Thienopyrimidine

Cite This Article

Ahmed, O., Rahman, M. H. U., Najeeb, A., Noorullah, S. M., & Basha, S. A. A., (2013). Design, Synthesis and Anti-Inflammatory Activity of Certain Fused Novel Thienopyrimidines Derivatives. International Journal for Pharmaceutical Research Scholars, 2(4), 82-87.