Design, Synthesis, Characterization and Antimicrobial Screening of Novel 2-[Imino(Pyridin-2-yl)Methyl]-N-Phenylhydrazinecarbothioamide

Author(s)

Jyothi, C. N., Sekhar, D.

Author's Affiliation

Abstract

Microbial metabolite or synthetic analogs which inhibit the growth and survival of microorganism without serious toxicity to the host are called antibacterial agents. An “antifungal drug” is a medication used to treat fungal infections such as athlete’s foot, ringworm, candidiasis (thrush), and others. Thiocarbamate derivatives exhibit a wide range of biological effects such as antibacterial, antifungal and etc. Pyridyl-2-amidrazone derivatives exhibit antitubercular and antifungal activities. Drug-likeness is a qualitative concept used in drug design for how "drug-like" a substance is with respect to factors like bioavailability. It is estimated from the molecular structure before the substance is even synthesized and tested.  Molinspiration supports also internet chemistry community by offering free on-line cheminformatics services for calculation of important molecular properties (for example log P, polar surface area, number of hydrogen bond donors and acceptors). Synthesize thiocarbamate incorporated pyridyl-2-amidrazone and then evaluating them for antibacterial & antifungal activities. Drug-likeliness was calculated based on “Lipinski’s rule of five". The score is computed using many commercial and academic softwares like Molinspiration etc. To evaluate druglikeness better, the rules have spawned many extensions, for example one from a 1999 paper by Ghose et al. Molinspiration tools are written in Java, therefore are available practically on any computer platform.

Keywords

Carbothioamides, Druglikeness Score, Molinspiration Server, Lipinski’s Rule of Five, Anti-Fungal

Cite This Article

Ch. Naga Jyothi, & D. Sekhar. (2014). Design, Synthesis, Characterization and Antimicrobial Screening of Novel 2-[Imino(Pyridin-2-yl)Methyl]-N-Phenylhydrazinecarbothioamide. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(1), 752-756.