Development and Evaluation of Floating Sustained Release Bilayer Tablets Containing Lamivudine

Author(s)

Gupta, S., Kopparam, M.

Author's Affiliation

Abstract

Bilayer floating tablets of Lamivudine were developed by direct compression method. Immediate release layer contains 30mg of drug and super disintegrant sodium starch glycolate, serves the purpose of loading dose. Sustained release layer contained HPMC K4M, natural polymers like xanthan gum, guar gum, locust bean gum, karaya gum release the drug for 12 hrs time. Sodium bicarbonate and citric acid are used to produce effervescence. Floating lag time of optimised tablet is 92 sec, whereas floating duration is more than 12 hrs. FTIR results revealed that there was no interaction between drug and HPMC K4M / xanthan gum. The post compression parameters of developed tablet are satisfactory. In this study it was confirmed that the formulations containing HPMC K4M, have shown better floating properties and finally the formulation containing a combination of HPMC K4M and Xanthan Gum in 3:1 ratio, has shown slower in vitro drug release properties. The release kinetics of optimised formulation prepared with the combination of HPMC K4M and xanthan gum followed zero order kinetics.

Keywords

Floating Bilayer Tablet, Lamivudine, HPMC K 4M, Xanthan Gum, FTIR

Cite This Article

Gupta, S. & Kopparam, M. (2015). Development and Evaluation of Floating Sustained Release Bilayer Tablets Containing Lamivudine, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(1), 224-235.