Development and Evaluation of Polyherbal Gel Formulation for Wound Healing Activity

Author(s)

Bharad, S.S., Deshmane, S.V., Biyani, K.R.

Author's Affiliation

Abstract

The plant Azadirachta indica belonging to family Meliaceae traditionally used in Ayurvedic system as insect repellant, antibacterial, anti-microbial effect, anti-fungal, anti-viral, anti-inflammatory and also strengthens the body’s overall immune responses Symplocos racemosa Roxb belonging to family Styraceae posses Antioxidant activity. Vitex Negundo Linn posses’ Antimicrobial activity, Antibacterial activity, Tinospora Cordifolia belonging to family Menispermaceae curative of dermatosis, Curcuma longa belonging to family posses wound healing activity. The aim of present study was to evaluate physical parameter with the  wound healing activity of Polyherbal gel; the different concentration of gel base Aqupec 505 HV HC with Azadirachta indica extract, Symplocos racemosa Roxb extract Vitex Negundo extract, Tinospora Cordifolia and Curcuma longa extract on the basis of physical parameter and in vitro drug release optimized batch was selected for wound healing activity by using a Partial thickness burn wound model in wistar males rats. All animals were divided into three groups. Group I was control. Group II was Test gel. Group III were treated by (Reference Standard) for 21 days all gel was applied topically. The wound healing activity was evaluated by physical parameters namely wound contraction and epithelialization. The polyherbal gel showed significant wound healing activity.

Keywords

Azadirachta Indica Extract, Symplocos Racemosa Roxb Extract, Vitex Negundo extract, Tinospora Cordifolia and Curcuma Longa, Aqupec 505, Mechanical Stirrer

Cite This Article

Bharad, S.S., Deshmane, S.V., Biyani, K.R. (2016). Development and Evaluation of Polyherbal Gel Formulation for Wound Healing Activity, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(2), 246-255.