Development and In Vitro Characterization of Sustained Release Pellets of Venlafaxine Hydrochloride

Author(s)

Remya, P.N., Damodharan, N., Dineshkumar, S., Sowjanya, V.

Author's Affiliation

Abstract

The present study was undertaken with development and in-vitro characterization of sustained release pellets of venlafaxine hydrochloride by wruster process technique .which release the drug in sustained manner over a period of 20 hours. The different viscosity grades of polymers are HPMC-E6, Ethyl cellulose 7cps, MCC-101 were preparation of granules or pellets by wurster coating .The granules were prepared and evaluated for Angle of repose, bulk density, tapped density, cars index, moisture content, stability studies and dissolution studies were carried out. Formulation f1 and f2 can be considered as an optimized formulation for disperse the drug freely in GIT tract of venlafaxine HCl for getting more bioavailability.

Keywords

Venlafaxine HCl, Pellets, Ethyl cellulose, Wruster process technique, Dissolution studies, Bioavailability

Cite This Article

Remya, P.N., Damodharan, N., Dineshkumar, S., Sowjanya, V. (2012). Development and In Vitro Characterization of Sustained Release Pellets of Venlafaxine Hydrochloride, International Journal for Pharmaceutical Research Scholars (IJPRS), 1(2), 437-443.