Development and Validation of Analytical Method for Simultaneous Estimation of Valsartan and Pioglitazone Hydrochloride by Simultaneous Equation Method

Author(s)

Jani, B. R., Shah, K. V.

Author's Affiliation

Abstract

The objective of the work is to develop analytical method for simultaneous estimation of Valsartan (VAL) and Pioglitazone hydrochloride (PIO). This method involve solving of simultaneous equations based on measurement of absorbances at two wavelengths 248 nm and 268 nm from 0.1N HCl solution and from phosphate buffer solution. Both the drugs obey the Beer’s law in the concentration ranges employed for this method. Results of the methods were validated statistically. Novel, simple, sensitive, rapid, accurate and economical spectrophotometric methods have been developed for simultaneous estimation of Valsartan and Pioglitazone hydrochloride. The method can be used to estimate the amount of Valsartan and Pioglitazone hydrochloride in formulation containing Valsartan and Pioglitazone hydrochloride.

Keywords

Valsartan, Pioglitazone hydrochloride, Anti hypertensive, Anti diabetic, Spectrophotometric analysis, Simultaneous equation method

Cite This Article

Jani, B. R., & Shah, K. V. (2014). Development and Validation of Analytical Method for Simultaneous Estimation of Valsartan and Pioglitazone Hydrochloride by Simultaneous Equation Method. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(3), 186-196.