Development and Validation of Spectrophotometric Method for Simultaneous Estimation of Etamsylate and Tranexamic Acid in Tablet Dosage Form

Author(s)

Naik, R.Y., Dedania, Z.

Author's Affiliation

Abstract

The present manuscript describe simple, novel, rapid, precise, accurate, specific and cost effective absorbance correction spectrophotometric method for the determination of Etamsylate and Tranexamic Acid in combined tablet dosage form. Here 0.01N Hydrochloric acid used as derivatizing agent and methanol as solvent for making Tranexamic Acid UV detectable.  Absorbance correction method involves measurement of absorbance at 305.29 nm for estimation of Etamsylate and measurement of corrected absorbance at 239 nm for estimation of Tranexamic Acid. The developed method was validated according to the International Conference on Harmonization (ICH) guidelines and all validation characteristics were found within the acceptance limits. Thus the proposed method can be successfully applied for simultaneous determination of Tranexamic Acid and Etamsylate in combined tablet dosage form.

Keywords

Etamsylate, Tranexamic acid, Absorbance Correction, Derivatization

Cite This Article

Naik, R.Y., Dedania, Z. (2015). Development and Validation of Spectrophotometric Method for Simultaneous Estimation of Etamsylate and Tranexamic Acid in Tablet Dosage Form, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(1), 149-156.