Development of Non-Effervescent Low Density Floating Tablets of Cefpodoxime Proxetil

Author(s)

Keerthy, H. S., Gowda, D. V., Deshpande, R. D., Siddaramaiaha, Datta, V.

Author's Affiliation

Abstract

The aim of the work is to modify the solubility and bioavailability of cefpodoxime proxetil, by employing noneffervescent floating drug delivery (tablet dosage forms). Non-effervescent systems are a type of floating drug delivery systems that have been used to boost the gastric residence and the floatation time in the gastro intestinal tract. The study included formulation of floating tablets using polymers like gum damar and HPMC K15M as matrix forming agents. Accurel® MP 1000 was used as floating agent. The tablets were prepared by direct compression technique. DSC studies conformed that there was no incompatibility between the polymer and the drug. Tablet preformulation parameters were within the Pharmacopoeial limit. Tablet showed zero lag time, continuance of buoyancy for >12 h. The tablet showed good in vitro release. Drug release was through swelling and abided by the gellation mechanism. In vivo X-ray studies depicted that tablets continued to float in the GIT for 12 h. Accelerated stability showed that, tablets were stable for over 6 month. Thus the prepared non-effervescent floating tablet of cefpodoxime proxetil can be used for the treatment of hypertension for more than 12 h with single dose administration.

Keywords

Cefpodoxime Proxetil, Accurel® MP 1000, Gum Dammar, HPMC K15M, Non-Effervescent

Cite This Article

Keerthy, H. S., Gowda, D. V., Deshpande, R. D., Siddaramaiaha, & Datta, V. (2014). Development of Non-Effervescent Low Density Floating Tablets of Cefpodoxime Proxetil. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(3), 69-77.