Effect of Microcrystalline Cellulose as a Filler / Diluent in Tablet Formulations

Author(s)

Roy, M.A., Sharma, P.H., Shiral, S.V.

Author's Affiliation

Abstract

Pharmaceutical Manufacturing is an important enterprise and oral tablet Manufacturing is the most significant of all, because more drugs are made as tablets than any other dosage form. Paracetamol or also known as Acetaminophen has been very well known as analgesic and antipyretic drug. Actually, these tablets were sold as OTC drug or even prescribed by doctors with high value of prize. Don’t you know, it’s easy to make and all ingredients were easy and cheap to purchased Microcrystalline cellulose (MCC) is a multifunctional excipient in drug formulation. However, the dependent of most developing countries on importation of this excipient invariably increases the cost of drug production. The tablet was prepared by taking different concentration of MCC. The prepare tablets for various paracetamol contain 10%, 20%, 30% of microcrystalline cellulose. From the study, it was observed that as the concentration  increase  the hardness, friability, dissolution, disintegration of paracetamol tablets are also affected. From this study, it is concluded that the concentration of MCC in tablet affect the various parameters and the drug release from tablet also affected.

Keywords

Paracetamol, Microcrystalline Cellulose (MCC), Friability, Dissolution, Disintegration

Cite This Article

Roy, M.A., Sharma, P.H., Shiral, S.V. (2015). Effect of Microcrystalline Cellulose as a Filler / Diluent in Tablet Formulations, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(3), 39-45.