Evaluation of Anti-inflammatory Activity of Cayratia pedata (Lam.) Juss. Leaf Extract in Some In vivo and In vitro Experimental Models

Author(s)

Rajmohanan, T.P., Nair, S.

Author's Affiliation

Abstract

Cayratia pedata (Lam.) Juss. Family: Vitaceae, finds many uses in folklore medicine including in the treatment of scabies, wounds, boils, skin ailments, diarrhoea, fever and inflammatory conditions. It is also used as an emetic, anthelmintic, astringent and rubefacient. The anti-inflammatory activity of the ethanol extract of leaves of C. pedata was evaluated using cotton pellet granuloma and granuloma pouch models in rats. An attempt to evaluate the possible mechanisms of action was also done on various in vitro models. It was shown that treatment with the C. pedata extract (250 and 500 mg/kg body weight, p.o.) significantly reduced the formation of granuloma and reduced the severity of inflammatory process in both the animal models. It is found that C. pedata leaf extract inhibits total cyclooxygenase in lipo-polysaccharide activated macrophages. The extract also exhibited significant proteinase inhibition activity in vitro.

Keywords

Cayratia pedata, Granuloma, Anti-inflammatory Activity, Cyclooxygenase, Lipoxygenase and Proteinase

Cite This Article

Rajmohanan, T.P., Nair, S. (2015). Evaluation of Anti-inflammatory Activity of Cayratia pedata (Lam.) Juss. Leaf Extract in Some In vivo and In vitro Experimental Models, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(3), 163-175.