Evaluation of Anti-Scorpion-Venom Property of Ethanolic Extract of Mimosa pudica in Albino Mice

Author(s)

Sunil, M., Premendran, J., Ranjana, B., Jayasree, T., Naveen, A.

Author's Affiliation

Abstract

Mesobuthus tamulus (red scorpion) is common in many parts of India, where morbidity and mortality due to stinging have been reported.  Prazosin is widely used for the management of the scorpion sting.  However, before the patient is taken to the hospital, certain herbal therapy can be tried in order to minimize the morbidity and complications.  Mimosa pudica is one such plant used for this purpose.  Therefore, we did a prospective randomized trial of scorpion venom versus Mimosa pudica plant extract alone and with prazosin in the treatment of severe Mesobuthus tamulus sting.  Swiss albino mice were used in the study.  Calculation of LD99 (Lethal dose) of Mesobuthus tamulus venom was done using Turner’s method. The mean survival time for the mice treated with LD99 dose was 3 minutes.    Acute toxicity of the scorpion venom and its neutralization by the plant extract in-vivo was done.  In the acute toxicity and in-vivo neutralization by plant extract in the dose of 1gm/Kg and 2gm/Kg resulted in the mean survival time of 7 minutes and 9.83 minutes respectively.  In combination of prazosin + plant extract the mean survival time was increased to 20.83 minutes.

Keywords

Mesobuthus tamulus, Mimosa pudica, LD99 (Lethal dose)

Cite This Article

Sunil, M., Premendran, J., Ranjana, B., Jayasree, T., Naveen, A. (2015). Evaluation of Anti-Scorpion-Venom Property of Ethanolic Extract of Mimosa pudica in Albino Mice, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(2), 372-377.