Evaluation of Anticancer Activity of Extract of Aphanamixis Polystachya (Wall.) Parker Leaves

Author(s)

Hegde, K., Moitra, G.

Author's Affiliation

Abstract

Cancer is a condition in which cells undergo uncontrolled proliferation which can be caused due to chemical agents, radiations or oxidative stress. Methanolic extract of leaves of Aphanamixis polystachya (MLAP) was studied for in vitro anticancer activity using T47D breast carcinoma cell lines and HeLa human cervical carcinoma cell lines and in vivo anticancer activity against EAC cell lines with two doses 200 mg/kg and 400 mg/kg. Radio protective activity of the extract was also studied on human breast carcinoma cell lines using UV radiation (15 W, 365 nm) with an exposure time of 15 min, with cell lines placed at a distance of 3 cm from the radiation. MLAP exhibited significant in vitro anticancer activity against T47D and HeLa cell lines and in vivo anticancer activity in EAC bearing mice with a potential of radio protection against UV radiation. These findings justify the traditional use of this plant in the treatment of cancer and validate its claim of being used for the said purpose in folklore claim.

Keywords

Anticancer, Aphanamixis Polystachya, EAC Cell Lines, Radio Protective Activity

Cite This Article

Hegde, K., & Moitra, G. (2014). Evaluation of Anticancer Activity of Extract of Aphanamixis Polystachya (Wall.) Parker Leaves. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 876-881.