Evaluation of Diuretic Activity of Alcoholic Extract of Cinnamomum Zeylanicum in Swiss Albino Rats

Author(s)

Naveen, A., Shankar, J., Prakash, M., Venkatnarayana, N., Naveen, P.

Author's Affiliation

Abstract

The present study was undertaken to evaluate the diuretic activity of alcoholic extract of Cinnamomum zeylanicum in swiss albino rats. The animals were divided into five groups with six rats in each group. First group of six rats were taken as control, and they received 0.9% normal saline 25ml/kg body weight orally. Second group of six rats were treated with standard drug hydrochlorothiazide 2.5mg/kg orally. Third, fourth and fifth groups were taken as test groups and they received the alcoholic extract of cinnamomum zeylanicum at the doses of 50,100 and 200mg/kg respectively. The diuretic effect of the extracts was evaluated by measuring urine volume, pH, sodium, potassium and chloride contents. Urinary volume was increased significantly with alcoholic extract of cinnamomum zeylanicum and this volume was maximum with 200mg/kg (P<0.001) in comparison with the control group. Cinnamomum zeylanicum showed maximum Na+ excretion with a dose of 100mg/kg (P<0.001) which is comparable with the standard drug hydrochlorothiazide. Potassium ion excretion was elevated significantly with increasing doses of the test drug and this K+ loss was more when compared with standard and control groups. Similarly chloride ion excretion was also elevated significantly with test group when compared with the control and standard groups. We conclude that alcoholic extract of cinnamomum zeylanicum showed significant saluretic effect but natriuretic and carbonic anhydration inhibition properties were found absent. Potassium loss was more with cinnamomum zeylanicum when compared with the standard drug which may cause significant electrolyte disturbances.

Keywords

Cinnamomum zeylanicum, Diuretic Activity, Urinary Volume

Cite This Article

Naveen, A., Shankar, J., Prakash, M., Venkatnarayana, N., Naveen, P. (2015). Evaluation of Diuretic Activity of Alcoholic Extract of Cinnamomum Zeylanicum in Swiss Albino Rats, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(2), 417-424.