Evaluation of Photo-degradation of Paracetamol Tablet in Various Packaging Modes in Bangladesh

Author(s)

Mohammad, H. R., Biswas, S., Bhuiyan, J. R., Mohammad, A. H., Mohammad, F. I.

Author's Affiliation

Abstract

Experiments were conducted on two local brands of paracetamol available in Bangladeshi pharmaceutical market, one is Napa (manufactured by Beximco Pharmaceuticals Ltd) and another is Parapyrol (manufactured by Glaxosmithkline). Though, these two brands are available in blister-transparent and strip packages respectively, blister-opaque (Alu-PVDC) was also used for these two brands along with two existing packaging systems to assess that which one provides better protection from photo degradation in comparison with others. Napa and Parapyrol both were brought on same environmental exposure and they were packaged in three packaging systems - blister-transparent, blister-opaque and strip. Half of the total tablets were kept in control condition at room temperature and another half were subjected to sunlight for the specific period of time. And it was ensured that both of these brands of paracetamol were equally exposed to sunlight. Then certain quality control tests (e.g. hardness, friability, and disintegration) were carried out to measure the changes due to sunlight exposure. Effect of sunlight on the potency of these two brands of three packaging systems was also measured. The assay of paracetamol content of the stored samples was carried out according to the BP (1993) method by extraction with 0.1M sodium hydroxide and measurement of absorbance at the maximum at 257 nm. The contents of paracetamol were calculated taking 715 as the value of A (1% 1cm) at 257 nm. It was observed that minute changes have been occurred both in physical quality and potency of the paracetamol of all aforementioned packaging systems due to the photo degradation.

Keywords

Paracetamol, Photo-degradation, Blister and Stability

Cite This Article

Mohammad, H. R., Biswas, S., Bhuiyan, J. R., Mohammad, F. I., & Mohammad, F. I. (2014). Evaluation of Photo-degradation of Paracetamol Tablet in Various Packaging Modes in Bangladesh. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 638-648.