Evaluation of the Anti hyperlipidemic and Anti atherosclerotic Activities of Ethanolic Extract of Cissus Pallida in Atherogenic Diet Fed Rat

Author(s)

Rahman, M. A., Durrai, V., Janardhan, pragathi, K. N., Deepa, R.

Author's Affiliation

Abstract

Atherosclerosis is one of the risk factors for coronary artery disease. Hyperlipidemia is an abnormally high level of fatty substances called lipids, largely cholesterol and triglycerides, in the blood. The present study highlights the anti hyperlipidemic and anti atherosclerotic activity of Ethanolic extract of Cissus Pallida preparation in atherogenic diet induced atherosclerosis in rats. Atherosclerosis was developed in male Albino Wistar rats, which were randomly divided into five groups of six animals each; by feeding with atherogenic diet for 45 days. Group 1 received normal diet. Group 2 received atherogenic diet (AD) which served as control. Group 3 served as standard, administered with Atorvastatin (50 mg/kg) along with AD and Group 4 and Group 5 were administered with ethanolic extract of Cissus Pallida preparation (250 mg/kg and 500 mg/kg) along with AD. Serum lipid profile, fecal cholesterol execration, and atherogenic index were estimated for all rats on the last day of the experiment. At the end of the experiment one rat from each group was sacrificed and aorta was isolated for histopathology studied. The results were analyzed statistically using analysis of variance (ANOVA). Ethanolic extract of Cissus Pallida preparation reduced the raised serum level of total cholesterol, triglyceride, LDL, VLDL and increased the serum HDL level as compared to the control group(AD).

Keywords

Atherosclerosis, Atherogenic Diet, Hyperlipidemia, Atorvastatin, Cissus pallid

Cite This Article

Rahman, M. A., Durrai, V., Janardhan, pragathi, K. N., Deepa, R. (2013). Evaluation of the Anti hyperlipidemic and Anti atherosclerotic Activities of Ethanolic Extract of Cissus Pallida in Atherogenic Diet Fed Rat. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(3), 132-138.