Fabrication and Release Kinetics Studies for Interpenetrating Polymeric Network (IPN) of Chitosan-Amino Acid Beads Loaded with BPM

Author(s)

Bhardwaj, H., Jaiswal, J., Sharma, N.

Author's Affiliation

Abstract

The present study was designed to synthesize the pH sensitive interpenetrating polymeric network (IPN) beads composed of chitosan-glycine-glutamic acid, cross linked with glutaraldehyde and their use for controlled drug release. The drug was loaded into beads by varying their composition. The beads were characterized by FTIR for cross linking reaction and drug interaction with cross linked polymer in beads and SEM to understand the surface morphology and internal structure and DSC to find out the thermal stability of beads. XRD investigation was carried out to determine the crystalline nature of drug after loading into chitosan-glycine-glutamic acid IPN beads. Results indicated amorphous dispersion of BPM (brompheniramine maleate) in the polymeric matrix. The results indicate that the cross linked IPN beads of chitosan-glycine-glutamic acid might be useful as a vehicle for controlled release of drug. The kinetics of drug release from beads was best fitted by Higuchi’s model in which release rate is largely governed by rate of diffusion through the matrix.

Keywords

IPN, FTIR, SEM, DSC, XRD, BPM, Higuchi’s model

Cite This Article

Bhardwaj, H., Jaiswal, J., & Sharma, N. (2014). Fabrication and Release Kinetics Studies for Interpenetrating Polymeric Network (IPN) of Chitosan-Amino Acid Beads Loaded with BPM. International Journal for Pharmaceutical Research Scholars, 3(1), 422-436.