Floating Drug Delivery System – A Review

Author(s)

Syed, M. S., Lalitha, C. V. S., Reddy, A. C., Surendra, P., Kalpana

Author's Affiliation

Abstract

In recent years, scientific and technological advancements have been made in the research and development of rate-controlled oral drug delivery systems by overcoming physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET). Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also known as Gastroretentive systems, hydrodynamically balanced systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices can remain in the gastric region for several hours and hence significantly prolong the gastric residence time of drugs. Prolonged gastric retention improves bioavailability, reduces drug waste, and improves solubility for drugs that are less soluble in a high pH environment. The purpose of writing this review is to focus on the principal mechanism of floating to achieve gastric retention. This review involves classification, mechanism of floating, factors affecting FDDS, in- vitro and in-vivo techniques and applications of these systems.

Keywords

FDDS, Single and Multiple Units, Evaluation Tests and Applications

Cite This Article

Syed, M. S., Lalitha, C. V. S., Reddy, A. C., Surendra, P., Kalpana. (2014). Floating Drug Delivery System - A Review. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 814-829.