Formulation and Characterization of Mouth Dissolving Tablet of Metoclopramide Hydrochloride

Author(s)

Shah, J.A., Patel, M.A., Patel, K.N., Patel, B.A., Patel, P.A.

Author's Affiliation

Abstract

Metoclopramide hydrochloride is an anti-emetic, act by blocking D₂ receptors in the Chemoreceptor trigger zone (CTZ), and antagonize chemotherapy induced vomiting. In the present study an attempt has been made to prepare Mouth Dissolving Tablets (MDTs) of Metoclopramide HCl for use in specific population viz. pediatrics, geriatrics and patients experiencing difficulty in swallowing tablet. Mouth Dissolving Tablets containing Metoclopramide HCl were prepared by direct compression method using various superdisintegrants like Sodium Starch Glycolate (SSG), Crosscarmellose Sodium (CCS), Crospovidone (CP), LHPC-11 and Doshion P 544D in three different concentrations i.e. 5, 7.5, 10 mg. The slight bitter taste of the drug was masked using sweetener and flavour which also enhanced the mouth feel of tablet. The initial compatibility studies between the drug and excipients were carried out using DSC and FT-IR Spectra. The blend was examined for various pre-compression parameters like angle of repose, density, compressibility index, etc. The formulated tablets were evaluated for hardness, friability, in-vitro disintegration time, drug content, etc. The hardness of the tablets was in range of 3-5 kg/cm². The percentage friability of the tablets was less than one. Weight variation test results showed that the tablets were deviating from the average weight within the permissible limits of ±7.5%. Drug content uniformity study results was found to be 99-100%. Batch F15 containing Doshion P 544D (10 mg) showed better disintegrating character along with the immediate release (100.09% within 6 minutes). There was no drastic change in result of tablets of an optimized batch at the end of one month accelerated stability study. It was concluded that the in-vitro drug release was influenced greatly by the concentration of superdisintegrants and Doshion P 544D was found to be better suited for the formulation of mouth dissolving tablets of Metoclopramide HCl compared to other superdisintegrants used in the study.

Keywords

Metoclopramide HCl, Superdisintegrants, Mouth Dissolving Tablet, Direct Compression Method

Cite This Article

Shah, J.A., Patel, M.A., Patel, K.N., Patel, B.A., Patel, P.A. (2012). Formulation and Characterization of Mouth Dissolving Tablet of Metoclopramide Hydrochloride, International Journal for Pharmaceutical Research Scholars (IJPRS), 1(2), 145-154.