Formulation and Evaluation of Effervescent Tablet of Paracetamol and Ibuprofen

Author(s)

Patel, H.K., Chauhan, P., Patel, K.N., Patel, B.A., Patel, P.A.

Author's Affiliation

Abstract

Recently, fast-dissolving drug delivery system have started gaining popularity and acceptance as new drug delivery system, because they are easy to administer and lead to better compliance. Usually, elderly people experience difficulty in swallowing the tablet. Paracetamol having analgesic, antipyretic effect, they inhibit cyclooxygenase enzyme involved in prostaglandin (PG) synthesis but not in peripheral tissue while Ibuprofen inhibit prostaglandin (PG) synthesis in peripheral tissue so in this study Paracetamol and Ibuprofen combination used for analgesic, anti-pyretic and anti-inflammatory action simultaneously. The aim of this study was to formulate effervescent tablet with sufficient mechanical integrity and to achieve faster disintegration in the water. Effervescent tablets are uncoated tablets that generally contain acid substances and carbonates or bicarbonates and which react rapidly in the presence of water by releasing carbon dioxide. They are intended to be dissolved or dispersed in water before use. Effervescent compositions in the form of tablets are comprising a therapeutic agent, granulating agent, and an effervescent system which dissolve rapidly in water to yield an effervescent solution containing a completely dissolved therapeutic agent and a process for their preparation. In this study different ratio of Citric acid and Sodium bicarbonate was used, superdisintegrant like SSG and cross-providone was used, compared to cross-providone SSG decreases the Solution time of tablet. Granules prepared by Wet granulation technique and from the result it was found that the Particle size 355-500 μm of granules show good Solution time and Hardness property.

Keywords

Effervescent tablet, COX-1, COX-2, Paracetamol, Ibuprofen

Cite This Article

Patel, H.K., Chauhan, P., Patel, K.N., Patel, B.A., Patel, P.A. (2012). Formulation and Evaluation of Effervescent Tablet of Paracetamol and Ibuprofen, International Journal for Pharmaceutical Research Scholars (IJPRS), 1(2), 509-520.