Formulation and Evaluation of Hair Gel for the Treatment of Chronic Inflammatory Disorder Seborrheic Dermatitis

Author(s)

Sharma, M., Bhowmick, M., Pandey, G. K., Joshi, A., Dubey, B.

Author's Affiliation

Abstract

Dandruff is a condition in which dead skin cells from the scalp come off in scales that are visible on the hair. The scales are dry, white or greyish and appear as small patches, especially at the top of the head.  Dandruff may be a symptom of a more serious problem, such as seborrheic dermatitis. Various Antifungal agents are widely used in hair shampoos for the treatment of dandruff. These products show temporary effect for span of hours in a day on the scalp. Therefore, an attempt has been made for formulation of Ketoconazole Anti-dandruff hair gels which may give antidandruff action for number of hours. All the formulations were evaluated Active Content, Physical appearance, PH, Viscosity, Extrudability, Antifungal activity, Drug release Profile and Stability study. The formulation HG3 shows superior drug release than other formulations. In carbopol gel formulations, the drug release was decrease with increase in carbopol concentration Antimicrobial activity shows that formulation HG3 shows higher efficacy without any dermal irritancy. Moreover the optimized formulation showed no signs of irritation or inflammation.

Keywords

Dandruff, Ketoconazole, Anti-dandruff hair gel

Cite This Article

Sharma, M., Bhowmick, M., Pandey, G. K., Joshi, A., & Dubey, B. (2013). Formulation and Evaluation of Hair Gel for the Treatment of Chronic Inflammatory Disorder Seborrheic Dermatitis. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(4), 33-41.