Formulation and Evaluation of Herbal Gel of Boswellia Serrata for the Management of Gout

Author(s)

Pal, P., Shams, S., Alam, S.

Author's Affiliation

Abstract

Herbal medicine has become an item of global importance both medicinal and economical in the modern drug delivery system. Herbal remedies are getting increasing patient compliance as they are devoid of typical side effects of allopathic medicines. Considering these facts present study deals with Topical Drug Delivery system composed of boswellia serrata extract which are having Antiinflammatory activity in the form of  herbal gel  for management of gout were formulated using gelling agent such as aerosil.  The drug was evaluated on the basis of solubility, Ultraviolet Spectroscopy, Fourier-transform Infrared Spectroscopy, High Performance Liquid Chromatography, Differential Scanning Colorimetry study. Formulations were prepared by dispersion method with altering the ratio of additives. The prepared herbal gel was subjected for preliminary evaluation such as pH, viscosity, Spreadability, skin irritation study, in vitro drug release. Among the various formulations prepared F2 shows the best results as per the preliminary studies of appearance, viscosity, Spreadability and in vitro release. The drug interaction FT-IR studies, HPLC and DSC indicated that there was no chemical interaction between the drugs and the additives used in gel formulations. The in vitro drug release kinetics study depict that drug release mechanism follows Fickian diffusion.

Keywords

Boswellia Serrata, Aerosil, Dispersion Method, Gel

Cite This Article

Pal, P., Shams, S., & Alam, S. (2014). Formulation and Evaluation of Herbal Gel of Boswellia Serrata for the Management of Gout. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(3), 242-250.