Formulation and Evaluation of Microparticles for Controlled Delivery of Tramadol Hydrochloride

Author(s)

Patel, S.B., Patel, V.R., Patel, K.N., Patel, B.A., Patel, P.A.

Author's Affiliation

Abstract

Although Tramadol has less analgesic power than morphine, it presents fewer side effects and consequently is currently considered as a drug of choice in the treatment of chronic pain. The aim of the present work was to study preparation of controlled drug delivery of Tramadol HCl via oral route. Drug was encapsulated within polymethacrylate copolymer i.e. Eudragit RS100 and Eudragit RL100, by solvent evaporation method using acetone/liquid paraffin system. FTIR and DSC of Tramadol HCl and it combination with Excipients shows no change in peak of absorbance and melting point. Microparticles of different drug-polymer concentrations 1:1, 1:2, 1:3 and 1:4 were prepared. Magnesium stearate was used as droplet stabilizer and lubricant in concentration of 0.3% (v/v). Selected formulations were characterized for their micromeritics property, % yield, drug loading, particle size, surface morphology and release behaviour. In-vitro dissolution tests were performed by using dissolution media with two different pH i.e. 1.2 pH for 2 hrs and 6.8 pH for 10 hrs. All the selected formulations exhibited a controlled release for almost 12 hrs. Among the entire prepared batches F25 shows good % drug loading (48.33%), high % yield (93%) and good controlled release (98%) within 12 hrs. The mean particle size of microspheres ranged from 252 ± 24.54 μm. Scanning electron microscopy of microspheres revealed a spherical and uniform appearance with smooth surface. Stability study was performed for batch F10 shows 96.78% drug release in 12 hrs. Release of TmH was best fitted to Higuchi model and Korsmeyer-Peppas model because it presented highest values of correlation coefficient (R² = 0.9822).

Keywords

Tramadol HCl, Microparticles, Eudragit RS100 and RL100, Scanning Electron Microscopy

Cite This Article

Patel, S.B., Patel, V.R., Patel, K.N., Patel, B.A., Patel, P.A. (2012). Formulation and Evaluation of Microparticles for Controlled Delivery of Tramadol Hydrochloride, International Journal for Pharmaceutical Research Scholars (IJPRS), 1(2), 136-144.