Formulation and Evaluation of Multiparticulate System for Chronotherapeutic Delivery of Aceclofenac

Author(s)

Patel, K. J., Patel, D. S., Patel, P. B., Jain, H. N., Upadhyay, U. M.

Author's Affiliation

Abstract

The objective of present study was to develop colon specific multiparticulate formulation as chronopharmaceutical drug delivery system (ChrDDS) for treatment of rheumatoid arthritis, which are influenced by circadian rhythm. The basic design consists of a core multiparticulate system coated by various polymers to avoid premature drug release in upper GIT. This optimization occurs on the basis of various parameters like entrapment efficiency, production yield, mean size, swelling index and In vitro release study. The entrapment efficiency and production yield for ionic gelation method was found to be highest among all methods. Pectin (6%) concentration gave highest sustainable property and CaCl₂ (6%) concentration had a good cross linking property. Coating of the multiparticulate was done using chitosan and Eudragit S-100. The programmable chronopharmaceutical drug release has been achieved from Eudragit S-100 coated pectin multiparticulate over a 12 hrs period, consistent with the demands of chronotherapeutic drug delivery for rheumatoid arthritis.

Keywords

Aceclofenac, Chitosan, Eudragit S-100., Pectin, Sodium Alginate

Cite This Article

Patel, K. J., Patel, D. S., Patel, P. B., Jain, H. N., & Upadhyay, U. M. (2014). Formulation and Evaluation of Multiparticulate System for Chronotherapeutic Delivery of Aceclofenac. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 1-9.