Formulation and Evaluation of Naratriptan Orodispersible Tablets Using Superdisintergrants by Direct Compression Method

Author(s)

Kshirasagar, N., Senthil, K. K., Sravan, K. A., Malvey, S.

Author's Affiliation

Abstract

The present study deals with the formulation and evaluation of Orodispersible tablets (ODT) of Naratriptan, a typical Antimigraine drug which is highly appropriate as it has ease of administration for mentally ill, disabled and uncooperative patients. ODTs have better patient acceptance, compliance, improved biopharmaceutical properties and efficacy compared with conventional oral dosage forms as they quickly disintegrate/dissolve/disperse in saliva. In the present research work, an attempt was made to design ODTs by addition of super disintegrants. Experimental design was run with four batches containing different concentration of super disintegrants. The optimization results revealed that the effect of super disintegrants result in good disintegration profile of 7-8sec (Ideal ODT should disintegrate within 1min), dissolution profile shows that more than 90% of the drug releases within 10 minutes, and good dispersion pattern. Crospovidone (5%) and Croscarmellose sodium (4%) are better super disintegrants. The formula F4 possesses good disintegration and dissolution profile with additions of super disintegrants.  The prepared tablets by direct compression using super disintegrants pass all the quality control tests and FTIR studies reveal that there is no interaction between drug and excipients. This method can also be used to prepare ODTs of antiemetics, antiallergics, and cardiovascular agents etc which needs rapid onset of action.  Thus, faster disintegration and dissolution of Naratriptan ODT may give better therapy for the treatments of Migraine.

Keywords

Orodispersible tablets, Naratriptan, FTIR, L1% values

Cite This Article

Kshirasagar, N., Senthil, K. K., Sravan, K. A., & Malvey, S. (2013). Formulation and Evaluation of Naratriptan Orodispersible Tablets Using Superdisintergrants by Direct Compression Method. International Journal of Pharmaceutical Research Scholars (IJPRS), 2(2), 268-278.