Formulation and Evaluation of Niacin Extended Release Tablets

Author(s)

Kumar, Y. M., kumar, M. K.

Author's Affiliation

Abstract

Present study aims to prepare and evaluate niacin extended release tablets.  The Matrix tablets each containing 1000 mg of niacin are formulated employing ethyl cellulose (10cps & 50cps)/ eudragits (FS-30D, NE-40D, RL-30D) in various proportions as rate controlling polymers. All the matrix tablets are prepared by wet granulation method and are evaluated for hardness, friability, average weight, and dissolution rate. A total of 10 formulations are prepared and estimated for comparison, dissolution rate of innovator product (Niaspan) is also studied, among all formulations F10 is found to be the best as all properties including dissolution rate are similar to those of innovators product.

Keywords

Niacin, Extended release, Ethyl cellulose, Eudragits, Wet granulation

Cite This Article

Kumar, Y. M., & kumar, M. K. (2014). Formulation and Evaluation of Niacin Extended Release Tablets. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 602-608.