Formulation and Evaluation of Orodispersible Films of Bromhexine HCl – A Patient Friendly Approach

Author(s)

Ayre, A.P., Marathe, D.S., Borkar, S.

Author's Affiliation

Abstract

The present investigation was carried out with the objective of formulating orodispersible forms of the mucolytic drug, Bromhexine HCl to enhance convenience and compliance to the elderly and paediatric patients for better therapeutic efficacy. Orodispersible films of Bromhexine HCl were prepared by solvent evaporation technique. Formulation studies were carried out using different polymer combinations, the obtained films were evaluated for their appearance, color, elegance, continuity, texture, presence of air bubbles, stickiness to Petri dish, cracks, cuttings, and imperfections. Alginate and HPMC based films recorded the fastest disintegration when used alone and in mixtures with PVP-K25 and maltodextrin. Xanthan gum film had the longest disintegration time. Moreover, adding xanthan gum, Na CMC, and carbopol prolonged the disintegration time of HPMC and alginate films. A good correlation existed between the calculated dissolution rate of each film and its disintegration time. Formulas F1and F7 showed the highest resistance against moisture absorption and recoded tensile strength values of 15.47 and 17.16 kg/mm², respectively after storage. Films based on HPMC alone or in combination with other polymers exhibited high resistance against moisture absorption except with Na CMC. Alginate and xanthan gum based films had a higher affinity for moisture absorption. The addition of maltodextrin significantly decreased the percentage moisture absorption after storage at 97% relative humidity. This effect was concentration-dependent. Thus disintegration time of film was 25 s, drug content 92.4 % and drug release was 96.3 %. The developed formulation was found to be stable under the conditions tested.

Keywords

Bromhexine HCl, Orodispersible Film, Oral Drug Delivery, Solvent Casting

Cite This Article

Ayre, A.P., Marathe, D.S., Borkar, S. (2016). Formulation and Evaluation of Orodispersible Films of Bromhexine HCl - A Patient Friendly Approach, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(2), 64-71.