Formulation and Evaluation of Sustained Release Matrix Tablets of Lornoxicam Using Natural Polymers

Author(s)

Jadi, P.M., Rao, B.S., Kulkarni, S.V.

Author's Affiliation

Abstract

The objective of the present work is to design of sustained release matrix tablets of Lornoxicam influence of natural polymers on the release rate and in vitro evaluation. Lornoxicam is widely used member of non-steroidal anti-inflammatory and analgesic drug with short biological half- life. Lornoxicam is practically insoluble in water because of this reason it is suitable to develop sustained release matrix tablet using hydrophilic polymers. The natural polymers like Okra gum, Locust bean gum, orange peel pectin, Xanthan gum, Lactose were utilized in the formulation of matrix tablets containing Lornoxicam by wet granulation technique and evaluated for its in-vitro drug release. Natural polymers are hydrophilic in nature and rate controlling polymers. Granules were prepared and evaluated for loose bulk density, tapped bulk density, compressibility index and angle of repose, shows satisfactory results. Formulation was optimized on the basis of acceptable tablet properties (hardness, thickness, friability, drug content and weight variations), in vitro drug release and stability studies. All the formulations showed compliance with Pharmacopeial standards. The in vitro release study of matrix tablets were carried out in pH 1.2 HCl for 2 hours and pH 6.8 phosphate buffer for the remaining 10 hours as dissolution medium. Among all the formulations, F9 shows 98.89% of drug which was better controlled release at the end of 12 hrs. It has been found that the optimized formulation F9 containing 210 mg of Xanthan gum as drug retarding polymer shows better sustained effect for 12 hours.

Keywords

Lornoxicam, Okra gum, Locust bean gum, Orange peel pectin, Xanthan gum, Lactose, Matrix tablet, Sustained release, Wet granulation

Cite This Article

Jadi, P.M., Rao, B.S., Kulkarni, S.V. (2015). Formulation and Evaluation of Sustained Release Matrix Tablets of Lornoxicam Using Natural Polymers, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(2), 322-332.