Formulation and Evaluation of Sustained Release Matrix Tablets of Venlafaxine Hydrochloride Using Natural and Synthetic Polymers

Author(s)

Shravan, K.S., Ashok, K.P., Suresh., V.K.

Author's Affiliation

Abstract

The objective of the present work is to design sustained release matrix tablets of Venlafaxine Hydrochloride, evaluation of influence of natural, synthetic polymers on the release rate and in vitro drug release. The natural polymers like Ghatti gum, pectin and synthetic polymers like HPMC K- 100, SCMC were utilized in the formulation of matrix tablets. Matrix tablets were prepared by wet granulation technique. Granules were evaluated for loose bulk density, tapped bulk density, compressibility index and angle of repose, shows satisfactory results. The formulation was optimized by acceptable tablet properties (hardness, friability, drug content and weight variations), in vitro drug release and stability studies. All the formulations showed compliance with Pharmacopeial standards. The in vitro release study of matrix tablets were carried out in pH 1.2 HCl for 2 hours and pH 6.8 phosphate buffer for the remaining 10 hours as dissolution medium. Among all the formulations, F-8 shows 98.89% of drug which was better-controlled release at the end of 12 hrs. It has been found that the optimized formulation F-8 containing a combination of HPMC and SCMC with each 75mg, as drug retarding polymers shows a better-sustained effect for 12 hrs, the results indicated that a decrease in release kinetics of the drug was observed by increasing the polymer concentration. The release data was fitted to various mathematical models to evaluate the kinetics and mechanism of the drug release. The stability studies revealed that the selected formulation was stable.

Keywords

Venlafaxine HCL, HPMC K 100, SCMC, Ghatti gum, Pectin, Matrix Tablets, Sustained release, Wet granulation

Cite This Article

Shravan, K.S., Ashok, K.P., Suresh., V.K. (2017). Formulation and Evaluation of Sustained Release Matrix Tablets of Venlafaxine Hydrochloride Using Natural and Synthetic Polymers.International Journal for Pharmaceutical Research Scholars (IJPRS), 6(2), 97-110.