Formulation and Evaluation of Sustained Release Matrix Tablets of Voriconazole Using Synthetic Polymers

Author(s)

Tejashwini, J.M., Ashok Kumar, P., Kulkarni, S.V.

Author's Affiliation

Abstract

The intention of this research work was to formulate, develop and evaluate the Sustained Release (SR) Tablets of anti fungal drug voriconazole. The tablets were prepared by wet granulation method. For the Sustained release formulation the dissolution time of the tablet must be optimized in order to have a prolonged release of drug in the dissolution profile. The dissolution time is managed by using polymers HPMC K100, Eudragit RSPO, HPMC K4M, and Carbopol 971P. In the formulations these trails were optimized by changing composition of polymer and its concentration. Micro crystalline cellulose used as diluent, Magnesium stearate as glidant, Talc as lubricant. The different excipients were tested for their compatibility with anti fungal drug voriconazole. The compatibility studies were carried out by FTIR and DSC studies and which shown that there was no chemical and physical interaction occurred. The preformulation parameters such as bulk density, tapped density, compressibility index and hausner’s ratio were analysed for prepared granules previous to compression. The thickness, hardness, friability, weight variation and drug content uniformity was evaluated for tablets. The effect of this variable on the drug release profile of voriconazole was also studied. The in-vitro drug release were performed in the USP Apparatus-II (Paddle) using 0.1N HCl  for l2 hrs and  remaining 10 hrs with 6.8phosphate buffer as a dissolution media at 100rpm speed and temperature of 37 ⁰ C ± 0.5 ⁰ C. The sampling was done at periodic time intervals of first two hours with 0.1N HCl and by changing the media with 6.8 phosphate buffer continue the dissolution up to 10 hrs. The cumulative amount of drug release at different time interval was estimated using UV spectroscopical method at 255nm,the F-7 Formulation containing Eudragit RSPO 10% shows release study up to 98.85%,these results indicate that the selected F -7 formulation was stable during the period of accelerated stability studies. All evaluated formulation results was found to be satisfactory.

Keywords

Sustained Release Tablets, Eudragit RSPO, HPMC K4M, Carbopol 971P, FTIR, DSC

Cite This Article

Tejashwini, J.M., Ashok Kumar, P., Kulkarni, S.V. (2015). Formulation and Evaluation of Sustained Release Matrix Tablets of Voriconazole Using Synthetic Polymers, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(2), 24-35.