Formulation Design and Development of Fast Disintegrating Tablets of “Lamotrigine” Using Liqui-Solid Technique

Author(s)

Sunium, M. S., Koteswari, P., Gopala, K. C. H., Babu, Y. B., Reddy, A. D.

Author's Affiliation

Abstract

Epilepsy is a disorder characterized by seizures which take various forms and result from episodic neuronal di Epilepsy is a neurological condition that is characterized by recurrent seizures. A seizure occurs when abnormal electrical activity affects a part or all parts of the brain. scharges, the form of seizure depending upon the part of brain affected. Fast dissolving dosage forms can be disintegrated, dissolved, or suspended by saliva in the mouth. Fast dissolving tablets are useful in patients, like pediatric, geriatric, bedridden, or mentally disabled. Construction of calibration curve Solubility studies and selection of non volatile solvent Selection of carrier and coat material ratio and calculation of loading factor Formulation of lamotrigine fast disintegrating tablets by liqui solid technique. Evaluation of powder blend for pre compression parameters such as Angle of repose, Bulk density, Tapped density and compressibility index Evaluation of Post compression Characteristics of Lamotrigine fast disintegrating liqui-solid tablets such as weight variation, Hardness, Friability, Disintegration and Dissolution tests. Application of mathematical models. I.e. is zero order, first order, hixon- crowel models to the in-vitro dissolution data Drug excipient compatibility studies using FT-IR Compilation and documentation of the data.

Keywords

Epilepsy, Calibration, FT-IR, Lamotrigine

Cite This Article

Sunium, M. S., Koteswari, P., Gopala, K. C. H., Babu, Y. B., Reddy, A. D. (2014). Formulation Design and Development of Fast Disintegrating Tablets of "Lamotrigine" Using Liqui-Solid Technique. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 305-316.