Formulation Development and Evaluation of Bi-Layer Tablet Containing Acetaminophen and Aceclofenac Layer by Solid Dispersion Technique

Author(s)

Mondal, S. M., Islam, A., Islam, A. M., Abuzar, S. M., Islam, T. M.

Author's Affiliation

Abstract

The objective of the study was to formulate bilayer tablets consisting of Acetaminophen and aceclofenac for immediate drug release. Bilayer tablets were prepared by using granules of Acetaminophen and solid dispersion of aceclofenac. Granules of Acetaminophen were prepared by wet granulation technique by using sodium starch glycolate (SSG) as super disintegrant, and sodium lauryl sulphate (SLS) used as surfactants to promote drug release in solid dispersion of aceclofenac. Bilayer tablets were evaluated for hardness, friability, weight variation, thickness and drug content uniformity and subjected to in vitro drug release studies. The amount of Acetaminophen and aceclofenac released at different time intervals were estimated by HPLC method. The bilayer tablets showed no significant change either in physical appearance, drug content or in dissolution pattern after storing at 40 °C/75% relative humidity (RH) for 3 months. Dissolution results of the entire tablet were analyzed with dissolution efficiency (% DE). These results indicated that release of the drug from the tablet was increased by content of super disintegrants and surfactants in solid dispersion technique.

Keywords

Acetaminophen, Aceclofenac, bi layer tablet, dissolution comparison

Cite This Article

Mondal, S. M., Islam, A., Islam, A. M., Abuzar, S. M., & Islam, T. M. (2013). Formulation Development and Evaluation of Bi-Layer Tablet Containing Acetaminophen and Aceclofenac Layer by Solid Dispersion Technique. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(3), 111-121.