Formulation, Evaluation and Optimization of Time and Enzyme Dependent Polymers Matrix Based Tablet for Colon Targeted Drug Delivery

Author(s)

Kurangi, B. K., Shah, R. R., Kemkar, V. U., Honarao, U., Mahajan, S. L.

Author's Affiliation

Abstract

The present research examines the physicochemical attributes of formulation needed to retard drug release of polymer matrix prior to its arrival at colon and evaluate the therapeutic value of polymer matrix in association with colon polyps. The colon specific drug delivery is a current need for the treatment of colon polyps or familial adenomatous polyposis (FAP), because the FAP is further converted into colon cancer. The colon targeted matrix tablets of Indomethacin were formulated by using pectin and HPMC K 100 M polymers. All the formulations were evaluated for hardness, drug content uniformity and other physical properties. The drug release studies were carried out in simulated gastric fluid of pH 4.5 followed by phosphate buffer pH 7.4 and pH 6.8 solutions. A 3² full factorial design was used for optimization by taking the amounts of HPMC K100M (X1) and Pectin (X2) as independent variables and percentage drug released at the end of 2^nd, 16^th and 24^th hours as dependent variables. X-ray Roentography study of the optimized batch tablet was carried out, from which it was concluded that colon targeting was successfully achieved.

Keywords

Indomethacin, Pectin, HPMC K100M, Roentography, Matrix Tablet

Cite This Article

Kurangi, B. K., Shah, R. R., Kemkar, V. U., Honarao, U., & Mahajan, S. L. (2014). Formulation, Evaluation and Optimization of Time and Enzyme Dependent Polymers Matrix Based Tablet for Colon Targeted Drug Delivery. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(1), 524-534.