Formulation of Microspheric Form of Silymarin and its Anticancer Potential on Cancercell Lines

Author(s)

KrishnaPillai, M., Thirumoorthy, N.

Author's Affiliation

Abstract

This present study was aimed to formulate microspheric form of Silymarin by using various polymers like Chitosan, Pectin, Carbopol 934P, Ethyl cellulose, Eudragit RS100. Microspheres were successfully prepared by emulsion solvent evaporation and ionic cross linking method. The prepared microspheres were evaluated for various parameters like encapsulation efficacy, swelling index, particle size, percentage yield, angle of repose, invitro release and evaluated for their invitro cytotoxicity potential. The obtained yields were varies from 46-91% on various polymers and encapsulation efficacy is up to 91.12%. Results from Invitro release studies indicated that, the microspheres of silymarin exhibited prolonged drug release for at least 12 h, and, therefore, could potentially improve the bioavailability of the silymarin. Results from invitro cytotoxic studies shows that, maximum percentage of cell viability is reduced up to 25 percentages at 12 hour which clearly indicated that 75 percentage cell deaths occurred in HT-29 colon carcinoma cells and DU145 Prostate carcinoma cells.

Keywords

Microspheres, Silymarin, Polymers, Invitro release study, Cytotoxicity

Cite This Article

KrishnaPillai, M., & Thirumoorthy, N. (2014). Formulation of Microspheric Form of Silymarin and its Anticancer Potential on Cancercell Lines. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 382-390.