Formulations of Sitopaladi Churna Granules and Tablets by Dry Granulation Technique for Enhancing Patient Compliance

Author(s)

Kumar, V. T. V., Manjunatha, K., Narayana, A. D. B.

Author's Affiliation

Abstract

The objective of this study was to improve the physiochemical properties such as poor flowability, organoleptic characters and stability of Sitopaladi churna.  Stability is the major concern affect the patient compliance and also dosage form. Granulation is required to overcome all these problems related to Sitopaladi churna. Granulation process will improve flow and compression characteristics, reduce segregation, improve content uniformity, and eliminate excessive amounts of fine particles. The present article focus on the dry granulation technology that gives good results based on evaluation of different granule properties, namely the Carr’s index, Angle of repose and tapped bulk density. Organoleptic evaluation and stability studies were also evaluated for prepared granules. Finally, the tableting process showed good tablet properties such as weight uniformity, hardness, friability, thickness and disintegration time. These properties were compared with corresponding marketed product. It indicating good compressibility of the prepared granules using different binders and stabilizing agents the selected formulations was stable.

Keywords

Sitopaladi Churna, Binders, Slugging, Granules, Organoleptic Studies, Stability Studies

Cite This Article

Kumar, V. T. V., Manjunatha, K., & Narayana, A. D. B. (2014). Formulations of Sitopaladi Churna Granules and Tablets by Dry Granulation Technique for Enhancing Patient Compliance. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 690-698.