Genotoxicity Study of Vinca difformis using Rat Bone Marrow

Author(s)

George, M., Joseph, L., Singh, B., Sabu, N.S.

Author's Affiliation

Abstract

The study aimed to investigate the phytochemical and therapeutic effects of aerial parts of Vinca difformis for genotoxicity activity in normal and cyclophosphamide treated group. Aerial parts of Vinca difformis was extracted with ethanol: acetone mixture. Presences of alkaloid, glycosides, steroids, phenolic compounds and volatile oils were identified in the extract. Genotoxicity studies showed that P>0.05 when compared to drug treated group with control and P<0.05 when compared to cyclophosphamide group and P<0.05 for drug with cyclophopshamide group in respect to control. Thus the results suggests that the aerial parts of Vinca difformis extract contains some active principles which may possess significant non-genotoxic activity.

Keywords

Genotoxicity, cyclophosphamide, chromosomal aberration, Vinca difformis

Cite This Article

George, M., Joseph, L., Singh, B., Sabu, N.S. (2016). Genotoxicity Study of Vinca difformis using Rat Bone Marrow, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(1), 108-113.