Hepatoprotective Activity of Fruit Extract of the Plant Sapindus Trifoliatus against CCl4 induced Hepatic Damage in Rats

Author(s)

Mishra, P., Panigrahi, B. B., Rath, R. S., Sarangi, B., Shukla N.

Author's Affiliation

Abstract

To investigate the effect of ethanolic and aqueous extract of pericarps of Sapindus trifoliatus (ST) in In - vivo models. (Family: Sapindaceae) Ethanol and aqueous fruit extracts of S. trifoliatus demonstrated hepatoprotective activity against carbon tetrachloride induced liver damage in rats. The parameters studied were serum total bilirubin, total protein, alanine transaminase, aspartate transaminase and alkaline phosphatase activities. The hepatoprotective activity was also supported by histopathological studies of liver tissue. Results of the biochemical studies of blood samples of CCl₄ treated animals showed significant increase in the levels of serum markers and decrease in total protein level reflecting the liver injury caused by CCl₄. Whereas blood samples from the animals treated with ethanol and aqueous fruit extracts showed significant decrease in the levels of serum markers and increase in total protein indicating the protection of hepatic cells. The results revealed that ethanolic extract followed by aqueous extract of S. trifoliatus fruit could afford significant protection against CCl₄ induced hepatocellular injury.

Keywords

Hepatoprotective activity, Sapindus trifoliatus (S.T.), SGOT (S.A.T.), SGPT, ALP, T.P.

Cite This Article

Mishra, P., Panigrahi, B. B., Rath, R. S., Sarangi, B., & Shukla N. (2014). Hepatoprotective Activity of Fruit Extract of the Plant Sapindus Trifoliatus against CCl4 induced Hepatic Damage in Rats. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 298-304.