In Vivo Study of Immunomodulatory Effect of Kalanchoe pinnata (Lam.) Pers.

Author(s)

Shaikh, H. Q., Dighe, V. V.

Author's Affiliation

Abstract

To study immunomodulatory activity of hydroalcoholic plant extract of Kalanchoe Pinnata (Lam.) Pers. The test animals chosen for the present experiment were Wistar albino rats. The tests carried out were haemagglutination inhibition, delayed type hypersensitivity test, complete blood counts and histopathology (Liver and Spleen). The plant extract of Kalanchoe Pinnata (Lam.) Pers. was evaluated for immunosuppressive activity using Cyclophosphamide as an immunosuppressive drug and for immunostimulant activity using Septilin as an immunostimulant drug. Humoral immune response was evaluated by withdrawing blood from immunized wistar albino rats for haemagglutination inhibition test. Cell mediated immune response was studied using paw edema test conducted on immunized wistar albino rats. The blood cell counts were evaluated for generalized study of effect of the plant drugs of Kalanchoe Pinnata (Lam.) Pers. Histopathological examination of liver and spleen were evaluated for the plant Kalanchoe pinnata (Lam.) Pers. The results obtained from the study indicate that the plant Kalanchoe Pinnata (Lam.) Pers. possesses immunosuppressant activity in vivo.

Keywords

Immunomodulatory activity, Kalanchoe Pinnata (Lam.) Pers., Wistar albino rats, Humoral immune, Cell mediated immune, Blood cell counts, Histopathology

Cite This Article

Shaikh, H. Q., & Dighe, V. V. (2015). In Vivo Study of Immunomodulatory Effect of Kalanchoe pinnata (Lam.) Pers., International Journal for Pharmaceutical Research Scholars, 4(4), 56-62.