Macrocyclic Complexes of Bioactive Divalent and Trivalent Transition Metal Ions Using Diethyl Malonate and Malonyldihydrazide

Author(s)

Wankhede, D. S., Wagh, P. B., Rajput, S. B., Karuppayil, S. M., Satare, S. S.

Author's Affiliation

Abstract

A series of seven macrocyclic complexes is synthesized by template condensation of diethyl malonate and malonyldihydrazide in methanolic medium in the presence of transition metal ions such as Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II). The synthesized complexes have been characterized with the help of molar conductance, magnetic susceptibility measurements, IR, electronic, and ¹H-NMR Spectra. On the basis of studies made a six coordinated octahedral geometry has been proposed for all these complexes. The synthesized complexes were also screened for their antifungal activity against human fungal pathogen Candida albicans and most of them have been found to exhibit significant antifungal activity.

Keywords

Diethyl Malonate, Malonyldihydrazide, Template Method, Octahedral, Antifungal Activity

Cite This Article

Wankhede, D. S., Wagh, P.B., Rajput, S. B., Karuppayil, S. M., & Satare, S. S. (2014). Macrocyclic Complexes of Bioactive Divalent and Trivalent Transition Metal Ions Using Diethyl Malonate and Malonyldihydrazide. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 766-774.